真皮的分层结构
真皮新视角
乳突真皮和网状真皮
真皮的上层称为乳突真皮，更深层称为网状真皮，他们的结构和功能都是不同的。这种分层结构是负责细胞外基质合成的成纤维细胞导致的。
应用于皮肤老化的重大科学发现
早在2007年，SILAB就开始了对真皮分层及老化的研究，开发出两种全新的抗衰老策略： PAPILACTYL D®，是化妆品市场上唯一的，能响应乳突真皮的靶向需求，对抗衰老影响的天然活性成分； RETILACTYL D®，一款紧肤的天然活性成分，能改善光老化对网状真皮的影响。
对基质组（MATRISOME）的详细研究
SILAB不断提升专业知识，通过检测基质组，一套细胞外基质及其关联蛋白的蛋白质基因编码。这项研究首次确定，乳突和网状成纤维细胞特异性基因表达署名与基质组相关。这些结果于2017年发表在著名的皮肤病研究杂志上。 SILAB对真皮分层的科学发现获得了3项专利并进行了9次国际交流。
Boudier et al., Matrix proteins of the papillary dermis - primary targets of intrinsic dermal aging? IFSCC Magazine, 11, 3, 2008
Boudier D. Le derme papillaire : première cible du vieillissement dermique intrinsèque, SFC podium presentation, 2008
Ruggiero F., Sorrel JM., Grässel S. The Papillary Dermis : Primary site of the intrinsic dermal aging, SILAB’s days podium presentation, 2008
Boudier et al., The papillary dermis: the first target of the chronological dermal aging, HPCI podium presentation, 2008
Boudier et al., Matricial proteins of the papillary dermis, new targets of intrinsic cutaneous aging?, IFSCC scientific poster, 2008
Boudier et al., Papillary dermis: a new biological target of the intrinsic cutaneous aging, SCC Annual Scientific Meeting podium presentation, 2010
Boudier et al., Papillary vs. Reticular fibroblasts: from the transcriptional analysis to the function, IFSCC podium presentation, 2010
Boudier et al., Human papillary and reticular dermis: two distinct compartments with two distinct sub-populations of fibroblasts, SFBMEC podium presentation, 2014
Nauroy et al., Human dermal fibroblast sub-populations display distinct gene signatures related to cell behaviors and matrisome. JID, doi:10.1016/j.jid.2017.03.028
Boudier et al., Fibroblastos papilares versus reticulares: del analisis transcripcional a la función, Cosmetica, 23, 3, 39-46, 2012.
Boudier D. Le derme papillaire : première cible du vieillissement dermique intrinsèque, SFC podium presentation, 2008
Ruggiero F., Sorrel JM., Grässel S. The Papillary Dermis : Primary site of the intrinsic dermal aging, SILAB’s days podium presentation, 2008
Boudier et al., The papillary dermis: the first target of the chronological dermal aging, HPCI podium presentation, 2008
Boudier et al., Matricial proteins of the papillary dermis, new targets of intrinsic cutaneous aging?, IFSCC scientific poster, 2008
Boudier et al., Papillary dermis: a new biological target of the intrinsic cutaneous aging, SCC Annual Scientific Meeting podium presentation, 2010
Boudier et al., Papillary vs. Reticular fibroblasts: from the transcriptional analysis to the function, IFSCC podium presentation, 2010
Boudier et al., Human papillary and reticular dermis: two distinct compartments with two distinct sub-populations of fibroblasts, SFBMEC podium presentation, 2014
Nauroy et al., Human dermal fibroblast sub-populations display distinct gene signatures related to cell behaviors and matrisome. JID, doi:10.1016/j.jid.2017.03.028
Boudier et al., Fibroblastos papilares versus reticulares: del analisis transcripcional a la función, Cosmetica, 23, 3, 39-46, 2012.
精选活性成分
这一专长是开发创新天然活性成分的源头，而这些成分能为皮肤提供多种美容益处。