Over the next years, research could improve the quality and length of human life in an unprecedented way. It would thus gradually erase the boundary between lifespan and healthspan.

Contrary to popular belief, the science of longevity corresponds to a complex ecosystem composed of several scientific disciplines that have given themselves the common objective of acting favorably for well-aging.

In trying to unravel the mysteries of longevity, scientific investigations have shed light on 12 key pathways and markers involved in biological aging ^[1]. They are references in understanding the failures of cellular machinery over time.

The skincare industry has not escaped the interest in the science of longevity. Revolutionary scientific advances in the understanding of the aging process have actively led to the identification of relations between biological aging.

A new vision of anti-aging, backed by experts from various medical fields and translating cutting-edge research into practical applications for skin care, supports the market in the development of emphasizing preventive care with healthy aging concept.

Unlike its traditional approach, longevity skincare changes the narrative from eradicating the signs of aging to harmonizing with them and creates solutions that address all generations of consumers. It offers the promise of caring and rational support for consumers tired of the idealization of youth.

Since its creation, SILAB has conducted numerous research projects on the phenomena that currently make up the circle of "hallmarks of aging".

For this article, SILAB has selected 6 high-performance natural active ingredients whose benefits have been supported by innovative models and confirm the decisive role of certain biological phenomena in skin aging.

SILAB solutions

EPIGENOMYL^® revitalizes the epigenome weakened by external aggressions and age. It prevents the modification of histones and regulates the production of miRNA. The elasticity of the skin is improved, its microrelief is smoothed, its uniformity and grain are reinforced.

ERISIUM^® maintains cellular proteostasis by preserving the health of the endoplasmic reticulum. It reactivates the UPR pathway, limits the inflammatory process and restores matrix dynamics. The quality of the dermal matrix is improved, wrinkles are reduced and the complexion radiance is revived.

CELLDETOX^® stimulates the autophagy pathway and strengthens cellular detoxification. It minimizes the accumulation of lipofuscin aggregates and thus contributes to cellular and tissue longevity. The skin's radiance is improved, microrelief and wrinkles are smoothed.

SENEVISIUM^® restores the elimination of immunoevasive senescent fibroblasts and protects the skin from their harmful effects on matrix synthesis and epidermal renewal. The skin regains its density and elasticity for an anti-wrinkle and radiance-boosting action.

UNFLAMAGYL^® regulates communication between senescent cells and their environment to limit the phenomenon of "inflammaging". It preserves the functionality of the dermo-epidermal junction and the dermis. The elasticity and tone of the skin are increased; the skin microrelief is smoothed.

ECOBIOTYS^® specifically rebalances the microbiota of mature skin by strengthening the skin's immune and mechanical barriers and acting on the distribution of bacterial communities. The quality of the skin barrier is improved, and the complexion is sublimated.