Sirtuins, guarantors of cell longevity

The science of longevity is subject driving research. Several mechanisms and markers that can limit the decline of biological functions have been identified in order to promote aging well. In particular, this is the case for sirtuins. Their effect on longevity depends on the availability of the coenzyme NAD+, required for the correct mitochondrial functioning and the production of energy, and of AMPK, an energy sensor that protects cellular metabolism.

Thanks to new studies conducted on different models of epidermal and dermal aging, SILAB has demonstrated the transversal action of LONGEVICELL^® on sirtuins 1, 3, 6 et 7 and their coactivators (NAD+ and AMPK). The active ingredient has thus positive effects on many mechanisms linked to aging, in particular by improving mitochondrial activity and limiting glycation and the onset of cell senescence.

A rapid anti-aging action on the face and body

Due to its favorable impact on these cell mechanisms, LONGEVICELL^® limits protein oxidation and boosts the production of cellular energy at the level of the epidermis, while improving the quality of the dermal matrix. 

As of 14 days, these effects are shown by remarkable benefits to the face and body: the skin of Caucasian and Asian volunteers is smoothed, and complexion radiance is revived. In addition, after 28 days, the skin gains in elasticity and firmness, and wrinkles are attenuated. These benefits are perceived by Caucasian volunteers themselves: 100% of them find their skin smoother (body) and more luminous (face) and 95% of them consider this care to be an anti-wrinkle product.

Study of the depth of wrinkles on a Caucasian panel (fringe projection).

A traceable, secure supply of myrtle, a plant that is a symbol of youth

Myrtle (Myrtus communis)

SILAB’s development of LONGEVICELL^® involved the optimal use of oligogalacturonans present in the leaves of myrtle. Native to the Mediterranean Basin, myrtle is a shrub appreciated for centuries for its capacity to glorify beauty. In Antiquity, Greco-Romans in particular used the essential oil of myrtle to prepare a floral water called “angel’s water” with the capacity of restoring freshness and youth to the complexion.

With concern for the sustainability of its supply chains, SILAB has selected Moroccan suppliers certified for organic agriculture for its sourcing. A control audit conducted by SILAB on the different steps used to produce the raw material has validated its quality and ensures its traceability back to the harvest site.

LONGEVICELL^® is a patented active ingredient recommended in all anti-aging face and body care products at a dose of 1 to 4%. Available in aqueous solution, it is easy to formulate. It complies with biodiversity regulations and has a natural origin content higher or equal to 99.3% (ISO 16128). It complies with international cosmetics regulations (Europe, USA, China, Japan, etc.).

Documentation available on the product page (connection to the private part required).