COMMUSYS^® is a natural anti-aging active ingredient rich in biopeptides derived from the yeast Pichia stipitis, which acts on transcompartmental communication. By regulating the molecular players involved in communication from the dermis to the epidermis (proteome, extracellular vesicles including exosomes, IGF-1 pathway), COMMUSYS^® reactivates epidermal biological functions. As a result, the skin of Caucasian and Asian volunteers is hydrated, smoothed and radiant.