PRO-COLL-ONE+^® contains a highly purified fraction of HRGPs glycopeptides obtained from soya. Both in vitro and in vivo studies were conducted in comparison with synthetic control molecules. It is demonstrated that PRO-COLL-ONE+^® is gifted with a powerful and targeted efficacy on collagen I synthesis. PRO-COLL-ONE+^® smoothes the surface microrelief and reduces crow’s feet wrinkles. True consolidator of the dermal mattress, PRO-COLL-ONE+^® is the indispensable anti-aging face care active ingredient.